Androgens and Female Sexuality: Molecular Insights, Neuroendocrine Crosstalk and Future Therapeutic Directions

Objective: The scientific community has recently directed its attention towards investigating the role of androgens in female sexuality. This narrative review aims to elucidate central and peripheral androgen-mediated mechanisms involved sexual health function. Additionally, current state androgen therapeutic options is discussed. Mechanism: We searched several literature databases, including EMBASE, MEDLINE, PubMed Central, Scopus, utilizing keywords, index terms, MeSH such as “androgen*”, “female sexuality”, function”, “women’s dysfunctions”, “androgen therapy women”, various combinations thereof. Findings Brief: Progesterone or estrogens are commonly prescribed first-line treatments for dysfunctions. However, these medications may frequently lead failure cause harm by increasing sex-hormone-binding-globulin plasma levels decreasing testosterone concentrations. Currently, there limited therapies available women, evidence their effectiveness safety still limited. Conclusions: knowledge neuroendocrine interactions that underlie arousal pleasure rapidly expanding, ongoing research striving develop more appropriate clinical practices managing dysfunctions women.